Paroxetine HCL

CAS no.: 78246-49-8
Molecular Formula: C19H21ClFNO3
Molecular Weight: 365.83
Appearance: white or off-white crystalline powder 
Product description: Paroxetine is new antidepressant and indicated for the treatment of various major depressive disorder. The efficacy of paroxetine is to be linked to potentiation of serotonergic activity in the central nervous system resulting from competitive inhibition of neuronal presynapse membrane reuptake of 5- hydroxylamine and cause the accumulation of the latter in synaptic cleft, help the impulsion transmission of 5-hydroxylamine to nerve. The selective is higher than fluxetin, sertraline and clomipramine. Paroxetine is not sedative actions. Normal dosage has no affect on heart rate and blood pressure. Paroxetine has very low affinity for cholinergic, histamine or adrenergic receptors. Adverse event in anti-cholin and cardiovascular is lower than tricyclic antidepressant desipramine. It did not produce impairment of intellectual function or psychomotor performance. The acute and chronic treatment was unchanged specifically in parameter of haematology, biochemistry and urogenital.