Cefquinome
Product description:Cefquinome is a fourth generation cephalosporin with pharmacological and antibacterial properties valuable in the treatment of coliform mastitis and other infections. It is only used in veterinary applications.
Cefquinome is resistant to beta-lactamase. Chemically, its zwitterionic structure can facilitate rapid penetration across biological membranes, including porins of bacterial cell wall. Plus, it has a higher affinity to target penicillin binding proteins. The reactive site is a beta-lactam nucleus, while the main peripheral functional groups are a quaternary quinolinium, an aminothiazolyl moiety and an unusual O-alkylated oxime.
Cefquinome acts by inhibition of the cell wall synthesis, but it has a relatively short half-life of about two and half hours. It is less than 5% protein bound and is excreted unchanged in the urine.
CAS No.:84957-30-2
Synonyms: 1-[[(6R,7R)-7-[[(2Z)-(2-Amino-4-thiazolyl)-
(methoxyimino)acetyl]amino]-2-carboxy-8-oxo-
5-thia-1-azabicyclo[4.2.0-oct-2-en-3-yl]methyl]-
5,6,7,8-tetrahydroquinolinium inner salt
Molecular formula: C23H24N6O5S2
Mol. mass: 528.60 g/mol
Structure:
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