Epiroprim
Product description:Epiroprim (EPM; Ro 11-8958) is a new selective inhibitor of microbial dihydrofolate reductase. EPM displayed excellent activity against staphylococci, enterococci, pneumococci, and streptococci which was considerably better than that of trimethoprim (TMP). EPM was also active against TMP-resistant strains, although the MICs were still relatively high. Its combination with dapsone (DDS) was synergistic and showed as in vitro activity superior to that of the TMP combination with sulfamethoxazole (SMZ).
CAS No.:73090-70-7
Synonyms: EPIROPRIM;Ro-11-8958;5-(3,5-DIETHOXY-4-PYRROL-1-YL-BENZYL)-PYRIMIDINE-2,4-DIAMINE;2,4-Diamino-5-[3,5-diethoxy-4-(1H-pyrrol-1-yl)benzyl]pyrimidine;EPIROPRIM:5-(3,5-DIETHOXY-4-PYRROL-1-YL-BENZYL)-PYRIMIDINE-2,4-DIAMINE
Molecular formula: C19H23N5O2
Formula weight: 353.41822
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