Rufinamide Metabolism

Rufinamide is abundantly metabolized but has no alive metabolites. Metabolism by carboxyesterases into abeyant metabolite CGP 47292, a carboxylic acerbic derivative, via hydrolysis is the primary biotransformation pathway. A few accessory added metabolites were detected in urine, which appeared to be acyl-glucuronides of CGP 47292. The cytochrome P450 agitator arrangement or glutathiones are not complex with the metabolism of rufinamide. Rufinamide is a anemic inhibitor of CYP 2E1. Rufinamide is a anemic inducer of CYP 3A4 enzymes.