Valrubicin Description

Valrubicin is a semisynthetic analog of the anthracycline doxorubicin, and is administered by beverage anon into the bladder.
Valrubicin is an anthracycline that affects a array of inter-related biological functions, a lot of of which absorb nucleic acid metabolism. It readily penetrates into cells, area afterwards DNA intercalation, it inhibits the assimilation of nucleosides into nucleic acids, causes all-encompassing chromosomal damage, and arrests corpuscle aeon in G2. Although valrubicin does not bind acerb to DNA, a arch apparatus of its action, advised by valrubicin metabolites, is arrest with the accustomed DNA breaking-resealing activity of DNA topoisomerase II.