Fludarabine Phosphate
CAS: 75607-67-9
Molecular Formula: C10H13FN5O7P
Molecular Weight: 365.2
Product description:Phosphorylation in the body was quickly to become 2 f - ara - A, the latter can be cells to absorb, and then by intracellular DNA cytidine kinase phosphorylation triphosphate become active after 2 f - ara - ATP. The metabolites can inhibit ribonucleic acid reductase, DNA polymerase alpha and delta, DNA primers enzymes and DNA ligase activity to inhibit the synthesis of DNA. Also can partially inhibit the activity of RNA polymerase Ⅱ reducing protein synthesis.
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