Cilastatin
Product description:Cilastatin is a chemical compound which inhibits the human enzyme dehydropeptidase.
Dehydropeptidase is found in the kidney and is responsible for degrading the antibiotic imipenem. Cilastatin is therefore combined intravenously with imipenem in order to protect it from dehydropeptidase and prolong its antibacterial effect. However, cilastatin itself does not have antibiotic activity.
Another carbapenem, meropenem is resistant to dehydropeptidase; therefore, it can be given without cilastatin.
CAS No.:82009-34-5
Synonyms: (Z)-7-[(2S)-2-Amino-3-hydroxy-3-oxopropyl]sulfanyl-2-[[(1S)-2,2-dimethylcyclopropanecarbonyl]amino]hept-2-enoic acid
Molecular formula: C16H26N2O5S
Molecular weight: 358.45
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