Tacrine
CAS: 321-64-2
Molecular Formula: C13H14N2
Molecular Weight: 234.725
Product description:From the concentrated hydrochloric acid yellow needle crystal, melting point of 283 ~ 284 ℃. Bitter taste. Soluble in water. 1.5% aqueous solution of the pH value of 4.5 ~ 6.High lipid solubility and easy through the blood brain barrier, has inhibition to AChE, is commonly used drugs. For the first generation of reversible anticholinesterase (AChE) inhibitor, inhibit AChE with increasing the content of acetylcholine (ACh) can inhibit AChE in the plasma, and inhibition of AChE in the organization; Can also be excited M and N receptors, and promote the ACh release; Also can promote the use of brain tissue to glucose. As a result, he kling effect on the treatment of alzheimer's disease is the result of interaction of many sided, is currently the most effective drug treatment.
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