Selumetinib
CAS: 606143-52-6
Molecular Formula: C17H15BrClFN4O3
Molecular weight:457.685
Appearance:white powder
Purity:99%
Storage:Avoid exposure to sunlight,Keep dry
Product description : Selumetinib is an ATP-independent inhibitor of mitogen-activated protein kinase kinase (MEK or MAPK/ERK kinase) 1 and 2. MEK 1 and 2 are dual specificity kinases that are essential mediators in the activation of the RAS/RAF/MEK/ERK pathway, are often upregulated in various cancer cells, and are drivers of diverse cellular responses, including proliferation. Inhibition of both MEK1 and 2 by selumetinib prevents the activation of MEK1/2 dependent effector proteins and transcription factors, thereby leading to an inhibition of cellular proliferation in various cancers.
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