Leflunomide

CAS: 75706-12-6
Molecular Formula: C12H9F3N2O2
Molecular Weight: 270.21
Product description:Is one kind has antiproliferative activity of different pbo immunosuppressants, modern pharmacology will this product as antipyretic and analgesic anti-inflammatory drug. This product by the liver and intestinal wall and microsomal rapidly into the cytoplasm of active metabolite and play a role, the main mechanism for the inhibition of DNA synthesis in the process of a key enzyme - dihydro orotic acid dehydrogenase activity (DHODH), so that the consumption as the nucleotides of B lymphocyte in termination of the biosynthesis of DNA and RNA, unable to enter the cell S period, finally can't proliferation, anti-rheumatism effect thereby, is suitable for the treatment of active rheumatoid arthritis, ankylosing spondylitis, adults can slow down the bone destruction, alleviate the symptoms and signs.