Irinotecan Hydrochloride

CAS: 136572-09-3
Molecular Formula: C33H38N4O6·HCl
Molecular Weight: 623.14
Product description:This product is like a tree antineoplastic alkaloids in plants such as - water soluble derivative of camptothecin. Type inhibits Ⅰ isomerase DNA topology configuration of DNA synthesis, which showed antitumor activity. This product test inhibit the activity of the cells in vitro is weak, but its metabolites of SN - 38 activity and adriamycin same or more.This product is administered by several times, anti-tumor effect is better. With CPA, pyrimidine and urea nitrate, ADM, cisplatin, ghost mortar b fork glucoside glycosides, 5 - FU, such as using, can enhance the anti-tumor effect. Therefore, this article wide antitumor spectrum, and with the existing antitumor drugs without cross resistance. This product and its metabolites of SN - 38 of the cell cycle specificity effects of S phase, the product main anti-tumor effect due to inhibition of DNA topology isomerase Ⅰ type, and block the synthesis of DNA.