Diazoxide

CAS: 364-98-7
Molecular Formula: C8H7ClN2O2S
Molecular Weight: 230.67
Product description:A drop in blood pressure medicine, have the basic structure of thiazide diuretic, but without a diuretic effect. Direct expansion of small arteries, veins no obvious effect. May through the activation of ATP sensitive potassium channels, make hyperpolarization arterial smooth muscle cells, smooth muscle relaxation effect, reduce the peripheral vascular resistance, decreased blood pressure. Step-down at the same time, heart rate, cardiac output is reduced. But the blood pressure to drop, can reflex sexual ground to excited sympathetic nerve cause tachycardia, myocardial contraction force strengthening, increased cardiac output, partly offset by antihypertensive effect of drugs, and can increase heart burden, cause or aggravate the angina pectoris, also make the renin secretion to increase, secondary to make aldosterone secretion increases, lead to water sodium retention. Combined application of b receptor blockers and diuretic to correct them. Apply to hypertensive crisis first aid, also used in litres of blood sugar, early childhood idiopathic hypoglycemia, severe hypoglycemia caused by pancreatic islet cell tumor.