Clofarabine

CAS: 123318-82-1
Molecular Formula: C10H11ClFN5O3
Molecular Weight: 303.68
Product description:Purine nucleoside derivatives, chlorine ferrari marina by inhibiting the nucleotide reductase role, reduce the cell DNA nucleoside triphosphate reserves, inhibit the synthesis of DNA; Through combine with DNA, competitive inhibition of DNA polymerase, so the extension of DNA and repair aborted. Chlorine ferrari marina triphosphate content on the affinity of these enzymes and DNA cytidine similar to or greater than. Preclinical studies have shown that in repair phase, chlorine ferrari marina through combination with DNA, inhibit DNA repair. Chlorine ferrari marina - 5 '- three compound phosphate can also break the mitochondrial membrane integrity, mitochondrial proteins leads to apoptosis, the release of cytochrome C, apoptosis inducing factor, eventually led to the programmed cell death.