Ceritinib

CAS: 1032900-25-6
Molecular Formula: C28H36ClN5O3S
Molecular Weight: 558.13514
Product description:ALK gene rearrangement is positive in the treatment of non-small cell lung cancer is a major problem. The azole resistance often occurs in g 1 year for his medical treatment. About one-third of patients with drug resistance is made up of ALK tyrosine kinase gene mutation or ALK gene amplification. Color red is for the second generation of oral ALK a tyrosine kinase inhibitors, it is not applied to MET proto-oncogene, but the inhibition of the insulin-like growth factor 1 receptor. In preclinical models, the color red for inhibiting ALK anti-tumor effect is g azole for 20 times.