Candesartan Ethyl Ester

CAS: 139481-58-6
Molecular Formula: C26H24N6O3
Molecular Weight: 0
Product description:Clinically for the treatment of essential hypertension, congestive heart failure. Candesartan ester is a kind of precursor drugs, the gastrointestinal absorption by hydrolysis, so that only candesartan ester in serum, and this is to block the activity of angiotensin receptor Ⅱ substances. Take 2 times a day, bioavailability is more than 40%, its function for 24 h blood pressure, mainly for the prototype eduction body outside, only 15% converted to inactive metabolites. Then the residual effect an average of 90%. The older angiotensin Ⅱ antagonist Losartan (Losartan) 24 h after drug, and 70% residual effect. At the end of the examination and approval department given time interval residual effect should be at least 50%. This effect lasts long, may be based on its high affinity for receptors. Compared with other anti-hypertensive drugs, small dose of candesartan ester have lower blood pressure.