3-Methyladenine

CAS:5142-23-4
Molecular formula:C6H7N5
Molecular weight:149.2
Product description:3-Methyladenine (3-MA, NSC 66389) is a widely used autophagy inhibitor, which can inhibit PI3K activity, limiting inhibition, inhibition of PI3K Vps34 stronger than PI3Kγ, IC50 25 μM, respectively , 60 μM. 3-Methyladenine in a time and dose dependent manner to reduce cell viability, and its associated caspase-3 activation. Under normal and starvation, 3-MA can cause cancer cell death and inhibit cell migration and invasion, the role regardless of their ability to inhibit autophagy. 3-MA phage blocking the formation of self, effective inhibition of intracellular protein degradation, however, has no effect on the intracellular protease activity, tobacco cells to inhibit autophagic response.