Fosmidomycin

Product name:Fosmidomycin 
Product description:Fosmidomycin is an antibiotic that specifically inhibits DXP reductoisomerase, a key enzyme in the non-mevalonate pathway of isoprenoid biosynthesis. It is a structural analogue of 2-C-methyl-D-erythrose 4-phosphate. It inhibits the E. coli enzyme with a KI value of 38 nM (4), MTB at 80 nM, and the Francisella enzyme at 99 nM.The discovery of the non-mevalonate pathway in malaria parasites has indicated the use of fosmidomycin and other such inhibitors as antimalarial drugs.Indeed, fosmidomycin has been tested in combination treatment with clindamycin for treatment of malaria with favorable results. It has been shown that an increase in copy number of the target enzyme (DXP reductoisomerase) correlates with in vitro fosmidomycin resistance in the lethal malaria parasite, Plasmodium falciparum.
CAS No.:66508-53-0
Synonyms: (3-(N-Hydroxyformamido)propyl)phosphonic acid;Fosmidomycina;Fosmidomycine 
Molecular formula:  C4H10NO5P  
Mol. mass: 183.100 g/mol