Plicamycin
Product name : Plicamycin
Synonyms : Antibiotic LA 7017;Mithramycin A;Plicamicina;NSC 24559;Plicamycinum
CAS No. : 18378-89-7
Molecular Formula : C52H76O24
Molecular Weight : 1085.15 g/mol
Product description :
Plicamycin is an antineoplastic antibiotic produced by Streptomyces plicatus. It is an RNA synthesis inhibitor.Plicamycin has been used in the treatment of testicular cancer,Paget's disease of bone, and, rarely, the management of hypercalcemia.Plicamycin has been tested in chronic myeloid leukemia.
Plicamycin is currently used in multiple areas of research, including cancer cell apoptosis and as a metastasis inhibitor.One elucidated pathway shows it interacts by cross-binding chromatin GC-rich promoter motifs, thereby inhibiting gene transcription.
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