Polymyxin B

Product name : Polymyxin B
Synonyms :
Bacilosporin;Mastimyxin;Aerosporin;Polmix;Polyfax;Thiosporin;Dynamyin;
CAS No. : 1405-20-5
Molecular Formula :  C56H100N16O17S  
Molecular Weight : 1301.56 g/mol
Product description :
Polymyxin B is an antibiotic primarily used for resistant gram-negative infections. It is derived from the bacterium Bacillus polymyxa. Polymyxin B is a mixture of two closely related compounds, polymyxin B1 and polymyxin B2. It has a bactericidal action against almost all gram-negative bacilli except the Proteus group. Polymyxins bind to the cell membrane and alter its structure, making it more permeable. The resulting water uptake leads to cell death. They are cationic, basic proteins that act like detergents (surfactants). Side-effects include neurotoxicity and acute renal tubular necrosis. It is commonly used in the topical first-aid preparation Neosporin.