Puromycin

Product name : Puromycin 
Synonyms : Adenosine-3'-(a-amino-p-methoxyhydrocinnamamido)-3'-deoxy-N,N-dimethyl;Stillomycin;Stylomycin;Antibiotic-P638;
CAS No. : 53-79-2
Molecular Formula :  C22H29N7O5  
Molecular Weight :  471.51 g mol−1
Product description :
Puromycin is an antibiotic that is a protein synthesis inhibitor by inhibiting translation.Puromycin is an aminonucleoside antibiotic, derived from the Streptomyces alboniger bacterium, that causes premature chain termination during translation taking place in the ribosome. Part of the molecule resembles the 3' end of the aminoacylated tRNA. It enters the A site and transfers to the growing chain, causing premature chain release. The exact mechanism of action is unknown at this time, but, the 3' position contains an amide linkage instead of the normal ester linkage of tRNA, the amide bond makes the molecule much more resistant to hydrolysis and thus causes the ribosome to become stopped.