2-Bromopyridine

CAS: 109-04-6
Molecular Formula: C5H4BrN
Molecular Weight: 158.00
Product description:Pale yellow oily liquid. For a long time or see the light color darker gradually.Soluble in ethanol, ethyl ether, slightly soluble in water.By 2 - aminopyridine via bromination. Industrial production is to hydrobromic acid (48%) cold below 0 ℃, slowly add 2 - aminopyridine, then under the salt bath frozen drops of liquid bromine, add speed to control the reaction temperature below 5 ℃ advisable. Plus after the drops and sodium nitrite solution, control reaction temperature under 0 ℃, stirring 20-30 min, and 50% sodium hydroxide solution, reaction liquid extracted with ether, washed, dry with anhydrous sodium sulfate, filtered, recycling ethyl ether, residue by reduced pressure distillation, collecting 88 ℃ to 94 ℃ / 3333 pa fractions, a quick finished product, yield of 83.8%.Organic synthesis, pharmaceutical intermediates. In the pharmaceutical industry for heart disease drugs synthesis isopropyl pyrazole amine (c pyrazole phosphate amine), etc.