Verrucarin A

Product name : Verrucarin A 
Synonyms :  muconomycin A;VER-A;
CAS No. : 3148-09-2
Molecular Formula :  C27H34O9  
Product description :
Verrucarin A is an inhibitor of protein synthesis. Verrucarin A partially inhibited the IL-8 production of a PMA-stimulated promyelocytic leukemia cell line (HL-60 cells), and the effect was related to the inhibition of NF-κB activation at noncytotoxic concentrations. Moreover, the inhibition of mitogen activated protein (MAP) kinase by verrucarin A was especially strong with p38- and JNK-phosphorylation. The findings show a new action of verrucarin A, and it is expected that this action relaxes the signal activation in response to stress.