Cycloguanil
Product name : Cycloguanil
Synonyms : Chlorguanide triazine;BRN 0229760;Cycloguanyl;
CAS No. : 516-21-2
Molecular Formula : C11H14ClN5
Molecular Weight : 251.715 g/mol
Product description :
Cycloguanil is a dihydrofolate reductase inhibitor, and is a metabolite of the antimalarial drug proguanil; its formation in vivo has been thought to be primarily responsible for the antimalarial activity of proguanil. However, more recent work has indicated that, while proguanil is synergistic with the drug atovaquone (as in the combination Malarone), cycloguanil is in fact antagonistic to the effects of atovaquone, suggesting that, unlike cycloguanil, proguanil may have an alternative mechanism of antimalarial action besides dihydrofolate reductase inhibition.
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