Amiodarone

CAS: 1951-25-3
Molecular Formula: C25H30ClI2NO3
Molecular Weight: 681.7725
Product description:The genus Ⅲ anti-arrhythmic drugs. Has a mild non-competitive alpha and beta adrenergic receptor blockers. And mild Ⅰ and Ⅳ anti-arrhythmic drug properties. The various parts of the main electrical physiological effect is to extend the myocardial tissue of action potential and effective refractory period, is helpful to eliminate the turn-back excited. Inhibit atrial and cardiac conduction fiber fast sodium ion flow, slow conduction velocity. Reduce the sinoatrial node self-discipline. The resting membrane potential and action potential height had no effect. The inhibition of atrioventricular bypass forward conduction is greater than the reverse. Due to the complex extremely excessive extension, electrocardiogram (ecg) have a Q - duration between T and T wave change. Static note had mild negative inotropic effect, but usually not inhibit left ventricular function. Have a direct expansion of coronary artery and peripheral vascular function. Can affect the thyroid hormone metabolism.